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Mitochondrial impairment serves as a key driver of ferroptosis by elevating reactive oxygen species and promoting the iron-mediated Fenton process, wherein ferrous ions facilitate the transformation of hydrogen peroxide into highly reactive hydroxyl radicals, thereby exacerbating oxidative damage and triggering ferroptotic cell death (121, 125, 126)
Anal Bioanal
Histidine persists in its neutral form between the pH of 6.00 (equivalent to pK a 3 for the side chain pyrrole NH group, which corresponds to the equilibrium between the positive and neutral form) and pH 9.17 (equivalent to pK a 2 of the amino group which corresponds to the equilibrium between the negative and neutral forms)
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